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KMID : 0604520220480040313
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Journal of the Society of Cosmetic Scientists of Korea
2022 Volume.48 No. 4 p.313 ~ p.319
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A Study on the Potency and Stability of the Cream Containing Cannabidiol Extracted Cannabis sativa L. from Korea
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Yu Sung-Dong
Kim Hye-Lim
Seong Ki-Jun
Jeon Jung-Tae
Song Ae-Ri
Kang Jong-Soo
Park Il-Bum
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Abstract
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In this study, the stability of cream containing 1% of cannabidiol (CBD) with more than 99% extracted from domestic Cannabis sativa was evaluated. The pH, hardness, content, and chromaticity were measured at intervals of 2 weeks under storage conditions for each temperature for 12 weeks (4 ℃, 25 ℃, 37 ℃, and 45 ℃). The pH of the experimental group containing 1% of CBD tended to decrease more than that of the control group. As a result of measuring the change in the content of CBD in the cream under each temperature for 12 weeks using HPLC, the difference in the amount of decrement according to temperature was confirmed. It was confirmed that as a result of measuring the chromaticity using color difference meter, the yellowness of the cream containing CBD increased according to the increase by the storage period and temperature compared to the control group. From the above results, it was confirmed that the content decrease and color change according to the temperature of the pH 5 ～ 6 cream formulation containing CBD. When CBD is applied to medicine and cosmetic formulations in the future, it is considered that research and development should be conducted in consideration of the change in the quantity and physicochemical quality of CBD under the temperature.
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KEYWORD
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cannabis sativa l., cannabidiol, cream, stability, color
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